Professors for Bioinformatic Program include CORE faculty and affiliated faculty. CORE faculty members include those that actively engage in teaching, student advising, committee work, qualifying exam and must be from Academia Sinica or cooperating universities (Chiao Tung University, Tsing Hua University, Yang Ming University). Those who are not CORE members but are interested in (helping out) occasional teaching or just be associated with are "affiliated faculty member".

Currently, members of the admission committee (Wen-Lian Hsu, Ting-Yi Sung, Ming-Jing Hwang, Grace Shwu-Rong Shieh, Chun-Hou Chen, Jenn-Kang Hwang, Chuan-Yi Tang, P. C. Lyu) are initial CORE members. Additional CORE members can be "recommended by" existing CORE members and concurred by a majority of them. CORE members can advise students, but an affiliated members can only co-advise a student with a CORE member. It is important to keep in mind that students need to publish their papers in bioinformatics related journals and conferences to graduate and part of that would be the responsibility of their advisers. There will be a committee to decide if the student has done adequate work before taking the final defense.

Bioinformatics Academic Committee makes the rules about required courses, qualifying exam, requirement for admission to candidacy and the final defense exam. Currently members include Wen-Lian Hsu, Ting-Yi Sung, Ming-Jing Hwang, Grace Shwu-Rong Shieh, Chun-Hou Chen, Jenn-Kang Hwang, Chuan-Yi Tang, P. C. Lu, Ueng-Cheng Yang and Kun-Mao Chao. Regardless of which universities a student is initially assigned to, his or her requirement for graduation should "only" follow those rules set by the Bioinformatics Academic Committee, not the rules of the individual university. Another important thing is that a student is free to choose an advisor with CORE members. If the Core member is not a joint faculty member with the university the student registered in, then a CORE faculty member of that university should agree to act as a co-advisor (but does not share credit for papers if no real collaboration exists).